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SIMICA'S NEWS


SIMICA Scholarship to attend international meetings

September 2021

For iMMers, the next cut-off date for the SIMICA Scholarship for the attendance of international conferences is the 27th September. Don’t miss the chance to attend an international scientific conference in 2021 and get the registration fee, traveling, accommodation and daily subsistence expenses covered.

For further details, please contact anamguerreiro@medicina.ulisboa.pt.


Science education

September 2021

IMM receives visits from students of secondary schools to engage them with research projects taking place at the institute. During last days Margarida Leite (Escola Secundária D. Martinho Vaz de Castelo Branco) and Afonso Cunha (Escola Secundária D. Rainha Leonor) visited our lab for 2 mornings. During their visits they were shadowing PhD students in the lab doing their work.


Work in progress

September 2021

Meeting between Bruno Oliveira and Ana Luiza from PERC to finalize the details of WP4 "Strengthening the innovation and entrepreneurship ecosystem".


Good luck Claúdia

September 2021

Claúdia Afonso, a PhD student at iMM, just started her exchange visit in the Chemistry Department of the University of Cambridge to work with Gonçalo Bernardes and Michele Vendruscolo. Over the next 6 months she will develop new chemical reactions for controlled acetylation of Tau protein to study neurodegenerative diseases.


Computational designed ADCs

September 2021

Dr. Daniel Zaidman, a Blavatnik Postdoctoral Fellow from Cambridge, visited iMM to explain how bioinformatics methods can be explored to design Antibody-Drug Conjugates with increased target specificity and affinity.  


Practical course in bioluminescence powered by PERC

September 2021

Last month Silvia Sobol from PERC organized a 1 day course about bioluminescent imaging at iMM. This course offered an integrated overview of the mechanisms and applications of bioluminescence for in vivo imaging, by covering all the key issues from the chemistry of bioluminescence to biological applications (e.g. visualization of tumor progression and metastasis).


Gonçalo presented at ISySyCat

August 2021

The International Symposium on Synthesis and Catalysis (#ISySyCat21) was great! Gonçalo Bernardes shared the latest advances on bioorthogonal bond-cleavage reactions for drug delivery. We are exploring these approaches for drug decaging from ADCs.


Well done Allcyte, well deserved

August 2021

We are proud to know that @Allcyte was acquired by @exscientiaAI to join forces on the discovery of better drugs using patient-first AI. It has been a privilege to have Allcyte on board. Further details here.


Upcoming seminar

August 2021

The SIMICA´s Seminars on Career Pathways invites speakers to discuss their path from Chemistry/Biology degrees to their current position, as well as to educate students about opportunities outside of academia. Our next speaker is Stuart Cantrill, Chief Editor of Nature Chemistry, that will speak about publishing in science on 11-11-2021. Save the date. Further details soon.


Thank you FCT for the funding

August 2021

Very happy to announce that our coordinator Bruno Oliveira just got his first grant as PI from the Portuguese Foundation for Science and Technology (FCT) focused on the combination of click chemistry and sequencing approaches to study potential roles of glycoRNA in cancer biology. This was a joint application with our partner Gonçalo Bernardes. Stay tuned!!


Results of the 3rd mentorship call

August 2021

Another successful mentorship programme established. On this call Luis Monteiro, a MD doing his PhD in the group of João Barata at IMM chose Bruno Oliveira as his mentor. Luis is interested in learning how to chemically modify a molecule that is being study in the lab to target Acute Myeloid Leukemia with the goal of improving its in vivo properties.


SIMICA paper highlighted by Bioconjugate Chemistry

July 2021


New publication about chemically triggered IEDDA reactions for protein modification

July 2021

Strained dienophiles are too unstable and unstrained dienophiles are too slow to react. Using an unstrained alkyne-BF3 dienophile we developed the first fast and chemically triggered IEDDA reaction for protein modification.


3rd mentorship call

July 2021

The call for the 3rd mentorship programme targeted at PhD students and postdoctoral researchers is now open from 19 July until 02 August 2021. If you have any questions please contact 
anamguerreiro@medicina.ulisboa.pt

Please meet the Twinning partners:


Our work is highlighted in a Bioconjugate Chemistry virtual issue

June 2021

We are happy to announce that our recent publication has been selected to appear in a virtual issue on “Bioorthogonal Chemistry and Bioconjugation” at Bioconjugate Chemistry.

See the message from the editors:

"Congratulations! We looked through a large number of papers to come up with what we felt best represented the most exciting advances in recent years, and we are very pleased to include your paper in the group. I hope you enjoy the issue, which can be found here. We would be grateful if you would let your coauthors know, and also spread the word to any colleagues who might take interest in the collection."

We thank the editors Vince Rotello, Jan van Hest, and Gang Zheng for the selection.


Exciting collaborations ahead with Neoleukin

June 2021

Our partner Gonçalo Bernardes is visiting the US for the next 2 weeks to discuss ongoing projects regarding the modification of de novo proteins as therapeutic agents for treatment of Acute Myeloid Leukemia. Stay tuned!


UCAM partner presented at the oncobiology club of iMM

June 2021

Mar Cabeza-Cabrerizo​​ from UCAM presented her work at iMM about "Development of multiparameter medical imaging tools for cancer diagnosis".


Dissemination material

June 2021

We will be sharing a series of flashcards for protein modification. Want to know how to improve stability of maleimides for bioconjugation? Check out our first flashcard. If interested download it here


Winners of the SIMICA scholarship call

May 2021

Congratulations for the following iMMers that won the 1st scholarship to attend an international conference:

  • Marta Marques, who will present her work on Exploring a CPO-probe as selective inhibitor of Human GAPDH at the FEBS Congress 2021 (3-8 July 2021), virtual meeting.
  • Bárbara Sousa, who will present her work on "From prostate to B-cell cancers: the importance of cysteine modification" at the conference Interfacing Chemical Biology and Drug Discovery RICT 2021 (7-9th July, 2021), virtual meeting.
  • Gonçalo Nogueira, who will present his work on "Effect of antiretroviral therapy on liver stage development of Plasmodium parasites and whole-organism vaccination against malaria " (25-27 May 2021), virtual meeting.
  • David Barata, who will present his work on "Development of a colorectal tumor-on-a- chip model for assessment of precision nanomedicine delivery" at the 11th World Congress on Alternatives and Animal use in the life sciences (23 August – 2 September 2021), virtual meeting.


SIMICA´s inspirational lectures

May 2021

Michele Vendruscolo from the Department of Chemistry, University of Cambridge, recently presented his work about "Rational Design of Conformation-Specific Antibodies Targeting Protein Aggregates". If you missed it you can now access the full lecture online.


SIMICA´s inspirational lectures

May 2021

Pablo Lara presented his work on extracellular vesicles for drug delivery. If you missed it you can watch it here.


Vicente de Seabra medal awarded to Gonçalo Bernardes

April 2021

Congratulations to Gonçalo for receiving the Vicente de Seabra 2020 medal from Sociedade Portuguesa de Química.


SIMICA scholarship for the attendance of international conferences

March 2021

The next cut-off date for the SIMICA scholarship for the attendance of international conferences is the 26th of April 2021.
If you are an IMMer, don’t miss the opportunity to attend an international scientific conference in 2021 and get the registration fee, travelling, accommodation and daily subsistence expenses covered. You just need to fill in the forms and send it to simicaimm@gmail.com .  The external evaluation panel will select the awardees. If you need any additional information please contact Ana Guerreiro, anamguerreiro@medicina.ulisboa.pt

Scholarship for the attendance of international conferences form

Biosketch SIMICA


Partnering in science

February 2021

COLife is an alliance between six research institutes in life sciences located in the region of Lisbon and Oeiras. Their main focus is to contribute to the cooperation and development of interdisciplinary science in the Lisbon area. More details can be found here https://colife.eu/en/. Their help has been of importance for the dissemination of our seminars.


Results of the 2nd mentorship call

February 2021

The second call of the SIMICA´´'S mentorship programme selected Christian Ramos, from Carmo Fonseca’s lab as a mentoree. Christian is a postdoctoral researcher and expects to improve his mentorship skills in RNA degraders and high throughput screening of cancer drugs in human tissue using high content imaging and deep learning.

His SIMICA mentors will be Gonçalo Bernardes (UCam) and Nikolaus Krall (Allcyte).

Congratulations Christian and good work!​


SIMICA news coverage in C&EN

January 2021

Work from our partner Gonçalo Bernardes at ChemCambridge is featured this week in C&EN. Wonderful work about “New system cuts RNA using only small molecules”. Please check https://cen.acs.org/biological-chemistry/rna/New-system-cuts-RNA-using/98/web/2020/11?utm_source=YMAL&utm_medium=YMAL&utm_campaign=CEN&utm_content=pos1


2nd mentorship call

January 2021

As part of its activities, SIMICA implements a mentorship programme targeted at PhD students and postdoctoral researchers. The next call for the SIMICA MENTORSHIP PROGRAMME will be open from 12 to 23 of January 2021. If you have any questions please contact anamguerreiro@medicina.ulisboa.pt


We need you!

January 2021

We are looking for a partner to organize a workshop about antibody production and purification. If you have any suggestion please contact us.


Happy New Year!

SIMICA wishes everyone a year full of discoveries and success.


Season greetings!

The SIMICA Twinning Project wishes everyone a Merry Christmas 🎅

https://twitter.com/SIMICA_iMM/status/1341036757538713600?s=20


New publication on methods for antibody modification

December 2020

Our paper about new carbonyl acrylate reagents for cysteine modification having Diels-Alder handles for in vivo pretargeting applications is out. This strategy allowed efficient coupling of the antibody Thiomab and a radiolabelled tetrazine at the tumor site to maximize targeting efficacy and reduce accumulation on non-target organs. Check it here!!!


Strengthening collaborations with Cambridge

November 2020

We are pleased to announce that SIMICA´s coordinator Bruno Oliveira was appointed visiting researcher at the Department of Chemistry, University of Cambridge.


Congratulations!

November 2020

To Gonçalo Bernardes for being one of 4 young scientists selected by the ICBS@ChemBioSociety to receive the 2020 Young Chemical Biologist award.

Bruno Oliveira has also been admitted as a Member of the Royal Society of Chemistry. As part of the RSC, new opportunities for collaboration and networking are created to enhance innovation on the field of antibody bioconjugation.


SIMICA first annual meeting

October 2020

The first annual SIMICA meeting was held on the 20th of October of 2020 in-person for Bruno Oliveira (iMM), Gonçalo Bernardes (UCAM), Alan Chan (PERC), Ana Luiza (PERC) or online for Katja Bierau (PERC), Luiz Cruz (LUMC) and Nikolaus Krall (Allcyte). The meeting had also the invaluable contribution of the Advisory Board Representatives, who also participated virtually through video conference.


Good luck Maria Rebelo

October 2020

We are pleased to announce that our first Staff-exchange visit is just ahead. Maria Rebelo is visiting the lab of Gonçalo Bernardes at Cambridge for the next 3 months.


SIMICA scholarship for the attendance of international conferences

June 2020

Due to the COVID19 pandemic the management team agreed in cancelling this call as the majority of the international conferences in 2020 were cancelled or postponed. A new call is expected to be open in March 2021. Stay tuned.


Results of the 1st mentorship call

May 2020

The first call of the SIMICA´'S mentorship programme selected Ravikumar Govindan which will be mentored by Dr Luis Cruz from LUMC. Ravikumar is a postdoctoral researcher at iMM and is interested in improving his skills on the field of nanomaterials for targeted drug delivery and bioimaging.


1st mentorship call

March 2020

The first call of the SIMICA mentorship programme is now open! The calls for this programme, targeted at PhD students and postdoctoral researchers, is opened every 6 months.

If you are an IMMer, don’t miss the chance to learn from our Twinning partners!


Our partner Allcyte is recruiting

February 2020

Allcyte team is growing! Allcyte is recruiting a lab manager / technical research assistant to support their translational efforts - for more information see: https://www.allcyte.com/careers


Our newsletter has a new face

January 2020

Our Newsletter N.2 is out, come and see the latest news here. Check also our new template!


Our website is online

November 2019

Have you checked out the SIMICA website? Stay tuned for upcoming SIMICA news here.


SIMICA´s Kick-off meeting

October 2019

The SIMICA'S´ Kick-Off Meeting took place on the 28th of October in Lisbon and was very profitable in terms of experience sharing regarding European projects and scientific discussion! Meet the SIMICA Consortium faces!

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