October 2021Antibody–drug conjugates represent one of the most promising and exciting areas of anticancer drug discovery. If you want to deep your knowledge about ADCs do not miss this excellent book from the RSC "Cytotoxic Payloads for Antibody–Drug Conjugates".
Meeting Peter Senter from SeaGen, world leader and pioneer in Antibody-Drug Conjugates
October 2021Seattle genetics was the first company to bring an ADC therapy (Adcetris) to the market. It is a privilege to have Peter Senter on our advisory board. Thank you for your insights and knowledge. Know the story behind Adcetris here.
October 2021Gonçalo Bernardes is the speaker of the next NCCR lecture (Nov. 29, 2021, 16:15). If you are interested on methods for protein modification, new bioorthogonal cleavage reactions for drug activation and RNA click-degraders please do registerand here bit.ly/g-bernardes
Another great meeting
It was good to discuss with Luis Cruz from LUMC and Ana Luiza from PERC the progress of the ongoing work about liposomes for drug delivery. Stay tuned for details. Ana, why so serious? :)
Results of the 2nd SIMICA Scholarship to attend international meetings
It is our pleasure to announce that three scholarships for the last call will be awarded to:
- Maria Rebelo - IDweek2021, annual meeting of the Infectious Diseases Society of America (IDSA),
- Rita Soares - XVII Meeting of the Portuguese Society for Neuroscience
- Ana Ramos - AD/PD 2022 International Conference on Alzheimer's and Parkinson's Diseases
SIMICA Scholarship to attend international meetings
For iMMers, the next cut-off date for the SIMICA Scholarship for the attendance of international conferences is the 27th September. Don’t miss the chance to attend an international scientific conference in 2021 and get the registration fee, traveling, accommodation and daily subsistence expenses covered.
For further details, please contact email@example.com.
IMM receives visits from students of secondary schools to engage them with research projects taking place at the institute. During last days Margarida Leite (Escola Secundária D. Martinho Vaz de Castelo Branco) and Afonso Cunha (Escola Secundária D. Rainha Leonor) visited our lab for 2 mornings. During their visits they were shadowing PhD students in the lab doing their work.
Work in progress
Meeting between Bruno Oliveira and Ana Luiza from PERC to finalize the details of WP4 "Strengthening the innovation and entrepreneurship ecosystem".
Good luck Claúdia
Claúdia Afonso, a PhD student at iMM, just started her exchange visit in the Chemistry Department of the University of Cambridge to work with Gonçalo Bernardes and Michele Vendruscolo. Over the next 6 months she will develop new chemical reactions for controlled acetylation of Tau protein to study neurodegenerative diseases.
Computational designed ADCs
Dr. Daniel Zaidman, a Blavatnik Postdoctoral Fellow from Cambridge, visited iMM to explain how bioinformatics methods can be explored to design Antibody-Drug Conjugates with increased target specificity and affinity.
Practical course in bioluminescence powered by PERC
Last month Silvia Sobol from PERC organized a 1 day course about bioluminescent imaging at iMM. This course offered an integrated overview of the mechanisms and applications of bioluminescence for in vivo imaging, by covering all the key issues from the chemistry of bioluminescence to biological applications (e.g. visualization of tumor progression and metastasis).
Gonçalo presented at ISySyCat
The International Symposium on Synthesis and Catalysis (#ISySyCat21) was great! Gonçalo Bernardes shared the latest advances on bioorthogonal bond-cleavage reactions for drug delivery. We are exploring these approaches for drug decaging from ADCs.
Well done Allcyte, well deserved
We are proud to know that @Allcyte was acquired by @exscientiaAI to join forces on the discovery of better drugs using patient-first AI. It has been a privilege to have Allcyte on board. Further details here.
The SIMICA´s Seminars on Career Pathways invites speakers to discuss their path from Chemistry/Biology degrees to their current position, as well as to educate students about opportunities outside of academia. Our next speaker is Stuart Cantrill, Chief Editor of Nature Chemistry, that will speak about publishing in science on 11-11-2021. Save the date. Further details soon.
Thank you FCT for the funding
Very happy to announce that our coordinator Bruno Oliveira just got his first grant as PI from the Portuguese Foundation for Science and Technology (FCT) focused on the combination of click chemistry and sequencing approaches to study potential roles of glycoRNA in cancer biology. This was a joint application with our partner Gonçalo Bernardes. Stay tuned!!
Results of the 3rd mentorship call
Another successful mentorship programme established. On this call Luis Monteiro, a MD doing his PhD in the group of João Barata at IMM chose Bruno Oliveira as his mentor. Luis is interested in learning how to chemically modify a molecule that is being study in the lab to target Acute Myeloid Leukemia with the goal of improving its in vivo properties.
SIMICA paper highlighted by Bioconjugate Chemistry
New publication about chemically triggered IEDDA reactions for protein modification
Strained dienophiles are too unstable and unstrained dienophiles are too slow to react. Using an unstrained alkyne-BF3 dienophile we developed the first fast and chemically triggered IEDDA reaction for protein modification.
3rd mentorship call
The call for the 3rd mentorship programme targeted at PhD students and postdoctoral researchers is now open from 19 July until 02 August 2021. If you have any questions please contact
Please meet the Twinning partners:
Our work is highlighted in a Bioconjugate Chemistry virtual issue
We are happy to announce that our recent publication has been selected to appear in a virtual issue on “Bioorthogonal Chemistry and Bioconjugation” at Bioconjugate Chemistry.
See the message from the editors:
"Congratulations! We looked through a large number of papers to come up with what we felt best represented the most exciting advances in recent years, and we are very pleased to include your paper in the group. I hope you enjoy the issue, which can be found here. We would be grateful if you would let your coauthors know, and also spread the word to any colleagues who might take interest in the collection."
We thank the editors Vince Rotello, Jan van Hest, and Gang Zheng for the selection.
Exciting collaborations ahead with Neoleukin
Our partner Gonçalo Bernardes is visiting the US for the next 2 weeks to discuss ongoing projects regarding the modification of de novo proteins as therapeutic agents for treatment of Acute Myeloid Leukemia. Stay tuned!
UCAM partner presented at the oncobiology club of iMM
Mar Cabeza-Cabrerizo from UCAM presented her work at iMM about "Development of multiparameter medical imaging tools for cancer diagnosis".
We will be sharing a series of flashcards for protein modification. Want to know how to improve stability of maleimides for bioconjugation? Check out our first flashcard. If interested download it here
Winners of the SIMICA scholarship call
Congratulations for the following iMMers that won the 1st scholarship to attend an international conference:
- Marta Marques, who will present her work on Exploring a CPO-probe as selective inhibitor of Human GAPDH at the FEBS Congress 2021 (3-8 July 2021), virtual meeting.
- Bárbara Sousa, who will present her work on "From prostate to B-cell cancers: the importance of cysteine modification" at the conference Interfacing Chemical Biology and Drug Discovery RICT 2021 (7-9th July, 2021), virtual meeting.
- Gonçalo Nogueira, who will present his work on "Effect of antiretroviral therapy on liver stage development of Plasmodium parasites and whole-organism vaccination against malaria " (25-27 May 2021), virtual meeting.
- David Barata, who will present his work on "Development of a colorectal tumor-on-a- chip model for assessment of precision nanomedicine delivery" at the 11th World Congress on Alternatives and Animal use in the life sciences (23 August – 2 September 2021), virtual meeting.
SIMICA´s inspirational lectures
Michele Vendruscolo from the Department of Chemistry, University of Cambridge, recently presented his work about "Rational Design of Conformation-Specific Antibodies Targeting Protein Aggregates". If you missed it you can now access the full lecture online.
SIMICA´s inspirational lectures
Pablo Lara presented his work on extracellular vesicles for drug delivery. If you missed it you can watch it here.
Raising public awareness
Disseminating our next lecture on FB. Don´t miss it on 21-05-2021.
Vicente de Seabra medal awarded to Gonçalo Bernardes
Congratulations to Gonçalo for receiving the Vicente de Seabra 2020 medal from Sociedade Portuguesa de Química.
SIMICA scholarship for the attendance of international conferences
The next cut-off date for the SIMICA scholarship for the attendance of international conferences is the 26th of April 2021.
If you are an IMMer, don’t miss the opportunity to attend an international scientific conference in 2021 and get the registration fee, travelling, accommodation and daily subsistence expenses covered. You just need to fill in the forms and send it to firstname.lastname@example.org . The external evaluation panel will select the awardees. If you need any additional information please contact Ana Guerreiro, email@example.com
Partnering in science
COLife is an alliance between six research institutes in life sciences located in the region of Lisbon and Oeiras. Their main focus is to contribute to the cooperation and development of interdisciplinary science in the Lisbon area. More details can be found here https://colife.eu/en/. Their help has been of importance for the dissemination of our seminars.
Results of the 2nd mentorship call
The second call of the SIMICA'S mentorship programme selected Christian Ramos, from Carmo Fonseca’s lab as a mentoree. Christian is a postdoctoral researcher and expects to improve his mentorship skills in RNA degraders and high throughput screening of cancer drugs in human tissue using high content imaging and deep learning.
His SIMICA mentors will be Gonçalo Bernardes (UCam) and Nikolaus Krall (Allcyte).
Congratulations Christian and good work!
SIMICA news coverage in C&EN
Work from our partner Gonçalo Bernardes at ChemCambridge is featured this week in C&EN. Wonderful work about “New system cuts RNA using only small molecules”. Please check https://cen.acs.org/biological-chemistry/rna/New-system-cuts-RNA-using/98/web/2020/11?utm_source=YMAL&utm_medium=YMAL&utm_campaign=CEN&utm_content=pos1
2nd mentorship call
As part of its activities, SIMICA implements a mentorship programme targeted at PhD students and postdoctoral researchers. The next call for the SIMICA MENTORSHIP PROGRAMME will be open from 12 to 23 of January 2021. If you have any questions please contact firstname.lastname@example.org
We need you!
We are looking for a partner to organize a workshop about antibody production and purification. If you have any suggestion please contact us.
Happy New Year!
SIMICA wishes everyone a year full of discoveries and success.
The SIMICA Twinning Project wishes everyone a Merry Christmas 🎅
New publication on methods for antibody modification
Our paper about new carbonyl acrylate reagents for cysteine modification having Diels-Alder handles for in vivo pretargeting applications is out. This strategy allowed efficient coupling of the antibody Thiomab and a radiolabelled tetrazine at the tumor site to maximize targeting efficacy and reduce accumulation on non-target organs. Check it here!!!
Strengthening collaborations with Cambridge
We are pleased to announce that SIMICA´s coordinator Bruno Oliveira was appointed visiting researcher at the Department of Chemistry, University of Cambridge.
To Gonçalo Bernardes for being one of 4 young scientists selected by the ICBS@ChemBioSociety to receive the 2020 Young Chemical Biologist award.
Bruno Oliveira has also been admitted as a Member of the Royal Society of Chemistry. As part of the RSC, new opportunities for collaboration and networking are created to enhance innovation on the field of antibody bioconjugation.
SIMICA first annual meeting
The first annual SIMICA meeting was held on the 20th of October of 2020 in-person for Bruno Oliveira (iMM), Gonçalo Bernardes (UCAM), Alan Chan (PERC), Ana Luiza (PERC) or online for Katja Bierau (PERC), Luiz Cruz (LUMC) and Nikolaus Krall (Allcyte). The meeting had also the invaluable contribution of the Advisory Board Representatives, who also participated virtually through video conference.
Good luck Maria Rebelo
We are pleased to announce that our first Staff-exchange visit is just ahead. Maria Rebelo is visiting the lab of Gonçalo Bernardes at Cambridge for the next 3 months.
SIMICA scholarship for the attendance of international conferences
Due to the COVID19 pandemic the management team agreed in cancelling this call as the majority of the international conferences in 2020 were cancelled or postponed. A new call is expected to be open in March 2021. Stay tuned.
Results of the 1st mentorship call
The first call of the SIMICA´'S mentorship programme selected Ravikumar Govindan which will be mentored by Dr Luis Cruz from LUMC. Ravikumar is a postdoctoral researcher at iMM and is interested in improving his skills on the field of nanomaterials for targeted drug delivery and bioimaging.
1st mentorship call
The first call of the SIMICA mentorship programme is now open! The calls for this programme, targeted at PhD students and postdoctoral researchers, is opened every 6 months.
If you are an IMMer, don’t miss the chance to learn from our Twinning partners!
Our partner Allcyte is recruiting
Allcyte team is growing! Allcyte is recruiting a lab manager / technical research assistant to support their translational efforts - for more information see: https://www.allcyte.com/careers
Our newsletter has a new face
Our Newsletter N.2 is out, come and see the latest news here. Check also our new template!
Our website is online
Have you checked out the SIMICA website? Stay tuned for upcoming SIMICA news here.
SIMICA´s Kick-off meeting
The SIMICA'S´ Kick-Off Meeting took place on the 28th of October in Lisbon and was very profitable in terms of experience sharing regarding European projects and scientific discussion! Meet the SIMICA Consortium faces!